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Directors' shareholdings

The table below shows the interests at 31 December 2007 or on the date of resignation (if earlier) of the persons who on that date were Directors (including the interests of their Connected Persons, as such term is defined in the Companies Act 2006) in shares and debentures of AstraZeneca PLC. All such interests were beneficial except as otherwise stated. None of the Directors has a beneficial interest in the shares of any of the Company’s subsidiaries. Between 31 December 2007 and 31 January 2008 there was no change in the interests in shares and debentures shown in the table below, with the exception of John Patterson who acquired a further 625 Ordinary Shares following the exercise of an option under the AstraZeneca Savings Related Share Option Plan.

DirectorBeneficial interest in Ordinary Shares at 1 Jan 2007 or appointment dateChange to
beneficial interest
Beneficial interest in Ordinary Shares at 31 Dec 2007 or resignation date
Louis Schweitzer4,0004,000
David Brennan111,7883,856115,644
John Patterson8,0158,015
Simon Lowth1850850
John Buchanan2,5002,500
Jane Henney500500
Michele Hooper500500
Håkan Mogren62,16462,164
Nancy Rothwell500500
John Varley500500
Marcus Wallenberg67,26467,264
Bo Angelin2500500
Former Directors
Jonathan Symonds311,52711,527
Peter Bonfield4500500
Joe Jimenez5500500
Erna Möller42,7182,718

1Part year only as appointed Director on 5 November 2007.
2Part year only as appointed Director on 25 July 2007.
3Part year only as ceased to be Director on 31 July 2007.
4Part year only as ceased to be Director on 26 April 2007.
5Part year only as ceased to be Director on 12 April 2007.

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